tag:blogger.com,1999:blog-8242319094148803910.post740679648504869915..comments2023-10-01T10:00:10.728-04:00Comments on You Are Where You Came From: Genetic GenealogyKathleen O'Harahttp://www.blogger.com/profile/06998207528481554149noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-8242319094148803910.post-68161082020772287722010-06-05T10:31:52.157-04:002010-06-05T10:31:52.157-04:00Wow, there are some really smart people reading th...Wow, there are some really smart people reading this!Kathleen O'Harahttps://www.blogger.com/profile/06998207528481554149noreply@blogger.comtag:blogger.com,1999:blog-8242319094148803910.post-80045869787987826182010-06-05T00:08:53.829-04:002010-06-05T00:08:53.829-04:00I felt compelled to leave a comment because I wrot...I felt compelled to leave a comment because I wrote my thesis on colon cancer, and what's the point of writing a thesis if not to make snobby comments? HNPCC is the name of a genetic disease, not a single mutation. It is a class of colon cancer that arises from inherited mutations. Some people with HNPCC have a mutation in one particular gene, while others with HNPCC can have a mutation in a completely different gene. So when she says "they've traced all cases of HNPCC back to one man ", she really means that they've traced one specific variant of HNPCC (in this case, she is probably referring to a MSH2 mutation*) to one man. Which is still pretty interesting. <br /><br />(*Source: http://jama.ama-assn.org/cgi/content/full/291/6/718?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=hnpcc&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT)<br /> <br />Genetics is cool!Michellehttps://www.blogger.com/profile/02425750469635997448noreply@blogger.comtag:blogger.com,1999:blog-8242319094148803910.post-36969885803775299262010-06-04T10:35:19.713-04:002010-06-04T10:35:19.713-04:00I see, then I don't suppose we have a cancer g...I see, then I don't suppose we have a cancer genetic disorder as there has been very little cancer in my family, but in reading so many death certificates from my ancestors I suspect other genetic disorders...more heart related. Thank you!Lisa Wallen Logsdonhttps://www.blogger.com/profile/13003873811444854964noreply@blogger.comtag:blogger.com,1999:blog-8242319094148803910.post-10782855155147241322010-06-04T07:51:44.344-04:002010-06-04T07:51:44.344-04:00HNPCC is hereditary. Most colon cancer is not. H...HNPCC is hereditary. Most colon cancer is not. However, if you suspect you may have a genetic disorder run in your family, you can visit a genetic counselor and be tested for HNPCC mutations. Some criteria to think about is how many people in your family have had cc and how old were they when they were diagnosed. HNPCC will affect generations and will cause cancer under the age of 50 in most cases. If you carry an HNPCC mutation, you have an 80% lifetime risk of developing cancer.Astridhttps://www.blogger.com/profile/00434175537509093484noreply@blogger.comtag:blogger.com,1999:blog-8242319094148803910.post-4188450215945845272010-06-04T07:17:21.741-04:002010-06-04T07:17:21.741-04:00This is really interesting! I did not know this wa...This is really interesting! I did not know this was purely genetic. My grandmother had colon cancer and is the only one in the family who has had it (that we know of). How do I find out more about this?Lisa Wallen Logsdonhttps://www.blogger.com/profile/13003873811444854964noreply@blogger.com